A 27-year-old disabled woman died at home weighing only 12kg, prompting the police to arrest her parents for murder by neglect, as they may have deliberately left her uncared for at their home.

The parents, both teachers, were arrested by police Monday morning at their home in the suburb of Brighton North, southwest of Adelaide, reported the Herald Sun.

The death was reported on March 19, and Adelaide detectives started an investigation as it seemed the woman had wasted away to weigh just 12kg at the time of her death.

The woman was reportedly bedridden, and she suffered a number of disabilities, including scoliosis.

The family's neighbours had told The Adelaide Advertiser they did not know the woman lived at the address.

The woman's parents, aged 56 and 55, lived with at least one other relative at their home, the Herald noted.

The couple will appear in court on Tuesday to face police allegations that they deliberately caused the death of their daughter by neglecting to adequately feed and care for her.