Actress Ellen Pompeo is Meredith Grey in the ABC series Grey's Anatomy
Actress Ellen Pompeo, of the series "Grey's Anatomy" arrives at the 2013 People's Choice Awards in Los Angeles, January 9, 2013. Reuters/Danny Moloshok

"Grey's Anatomy" Season 11 premieres on Sept. 25, 2014. After a long hiatus, the much anticipated Episode 1 titled "I Must have Lost it on the Wind" will bring together fan-favourite characters of the show. Additionally, the fans will meet some new characters. Here are some spoilers from "Grey's Anatomy" Season 11 Episode 1 (Premiere). [Warning: Spoilers Alert!]

This article contains spoilers from "Grey's Anatomy" Season 11 Episode 1 (Premiere) and more. Read at your own risk.

The 11th instalment of the long-running medical drama is going to introduce an intriguing twist in Meredith's life with the entry of new cardiothoracic head Maggie. Fans know that she is Meredith's half-sister, Richard and Ellis secret love child.

The network released a clip teasing the start of Maggie and Meredith's relationship. And it does not look too good. The scene opens with Alex warning Richard from going inside the conference room. Richard tries to overhear what's going on behind the doors. As the scene shifts, Meredith and Maggie can be seen involved in a major confrontation.

Maggie complains about being disrespected and unprofessionalism. Meredith counter attacks and they continue snapping at each other. (Scroll down to watch the video.) It seems the two do not know that they are sisters.

However, it won't take too long for the big news to spread. Based on photos from episode 2 and teaser by show's creator Shonda Rhimes, Entertainment Weekly speculates that the "Maggie-centric" segment may "include Meredith finding out the truth about who Maggie is."

Furthermore, it cites the big revelation Shonda Rhimes made to the entertainment news publication.

"There's a moment early on when [Amelia] finds herself the keeper of some secrets that Richard didn't necessarily want her to know by being at an AA meeting that he didn't know she was at," Rhimes told Entertainment Weekly.

"It draws her into the world in a deeper way than she anticipated," she added

Meanwhile, fans know that "Grey's Anatomy" Season 11 (2014) Episode 1 (Premiere) will see Meredith's emotional battle after Cristina is gone. At the same time, she struggles with her husband's decision of leaving Seattle. Furthermore, Callie and Arizona will make a decision related to surrogacy that could impact their relationship in a big way. Also, Bailey starts to see a rival in Alex and declares a fight for Cristina's chair on board of directors. A medical complication arises when a teenage couple meet with an accident while they are involved in a sexual act.

"Grey's Anatomy" Season 11 Episode 1 is written by Stacy McKee and directed by Kevin McKidd, the actor who portrays Dr. Owen Hunt. The show features Chandra Wilson, Patrick Dempsey, Ellen Pompeo, Sarah Drew and more. Season 11 Episode 1 (Premiere) "I Must Have Lost it on the Wind" is also expected to feature Oscar Winning actress Geena Davis' "Grey's" debut.

"Grey's Anatomy" Season 11 premieres Thursday, Sept. 25, 2014 at 8 p.m. ET on ABC. Fans can also watch the Episode 1 online via live stream here.

Video: Grey's Anatomy Sneak Peek 11.01 - I Must Have Lost It On The Wind (2)

Credit: YouTube.com/ Blue Sky6134

For more spoilers from "Grey's Anatomy" Season 11, read below:

'Grey's Anatomy' Season 11 Premiere (Episode 1) Spoilers: Things To Expect When The Show Returns

'Grey's Anatomy' Season 11 Premiere (Episode 1) Spoilers: Find Out What Happens In 'I Must Have Lost It On The Wind'