‘Grey’s Anatomy’ Season 12 Finale: ‘Family Affair’ focuses on Meredith, Jolex, Calzona, Amelia and Owen [SPOILERS]

Original air date, Greys 12x24: May 18 on ABC

“Grey’s Anatomy” Season 12, Episode 24 (“Family Affair”) airs May 19 on ABC. Directed by Debbie Allen (who also plays Catherine Avery), the twelfth season finale is expected to focus on Ellen Pompeo’s Meredith Grey, as well as the answer that Jo Wilson (Camilla Luddington) gave to Alex Karev (Justin Chambers). Callie (Sara Ramirez) and Arizona (Jessica Capshaw) try to deal with custody arrangements, while Amelia (Caterina Scorsone) and Owen (Kevin McKidd) face the idea of a wedding.

Spoiler alert: This update contains “Grey’s Anatomy” Season 12 spoilers. This year’s finale tackles Meredith’s kiss in the penultimate episode. Details from the 12x24 synopsis from ABC are also included. Fans can also watch the twelfth season finale of Grey's Anatomy finale on ABC Go.

In the final moments of Greys 12x23 (“At Last”), Meredith Grey and Nathan Riggs (Martin Henderson) kiss in the heat of a fiery argument. This encounter is expected to be explored in the finale episode, just as Jo’s refusal to marry Alex would also be tackled. Series creator Shonda Rhimes is likely to highlight that Meredith is moving on, but fans are divided on the possibility of a Meredith-Karev love story.

“Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement,” reads the ABC synopsis of “Grey’s Anatomy” Season 12, Episode 24. What secret could this be? In another couple drama, will Callie and Arizona be able to go back to a friendly space after all the court drama that Callie handled poorly, as far as Arizona is concerned.

While other couples are in some rocky (or shocking) situations, Amelia and Owen are finally settling down. The two start talking about marriage in Greys 11x23, and it seems they are ready to stop their poor pattern of starting over and then staying away from each other. But Amelia still panics moments before their wedding in a new promo video shared by ABC on the show's Facebook page.

“Meredith and Maggie (Kelly McCreary) support Amelia on an important day,” reads the ABC synopsis, which also adds, “Ben (Jason George) leaps into action to help a friend.” Meredith and Maggie are taking on important roles in Amelia and Owen's wedding ceremony, while Ben is helping out April Kepner (Sarah Drew), who seems ready to give birth in a promo video. Jesse Williams (Jackson Avery) is now going to be a dad, months after insisting on a divorce.

Connecting to the Japril arc are Catherine and Richard Webber (James Pickens Jr), who seem to be doing well as a married couple despite personality differences. The two are going to be grandparents now.

“Grey’s Anatomy” Season 12 has so far rarely made good use of its interns, particularly Joe Adler’s Isaac. All viewers learned this season is that he is really into Jo Wilson. Giacomo Gianniotti’s Andrew DeLuca gets a bit more screen time in connection to his short-lived romance with Maggie. Residents Wilson and Stephanie Edwards (Jerrika Hinton) enjoy more character developments, thanks to their association to Karev, Amelia and Meredith. Hinton also gets a tragic love story in Greys 12x23, where Wilmer Valderrama's Kyle Diaz dies on the table.

Written by Williams Harper, "Family Affair" is expected to be as memorable as most of “Grey’s Anatomy” finales. A year ago, the 11th season ended with Meredith showing a smile after about a year of grieving over the death of Patrick Dempsey’s Derek Shepherd.

WATCH: Greys 12x23 – Meredith, Riggs kiss at Grey Sloan Memorial parking (ABC on YouTube)