Jake Gyllenhaal and Anne Hathaway appear naked on the cover of the latest Entertainment Weekly issue. Are the two together? Yes, but only in an upcoming movie Love and Other Drugs. Gyllenhaal and Hathaway have previously worked together in the critically acclaimed Brokeback Mountain by Ang Lee.

Love and Other Drugs is based on the Hard Sell: The Evolution of a Viagra Salesman by Jamie Reidy and is directed by Edward Zwick. It revolves around Maggie, a free spirited woman played by Anne Hathaway, who then meets her match in Jamie, played by Gyllenhaal who works in pharmaceutical sales. Love and Other Drugs is set to be released next week, on November 24, 2010.

Jake Gyllenhaal, who has been shortlisted for People's Sexiest Man Alive this year, revealed how it was to work with Anne Hathaway in their new film, where the Rachel Getting Married actress is often shot naked on the set.

"I mean, look. I've had a pretty illustrious career at this point but the hardest thing has been pretending to be turned on by Anne Hathaway," Jake kid on his guesting at the The David Letterman Show.

Love and Other Drugs features a love scene between Jake and Hathaway, and Jake revealed that the scene is actually very carefully planned out, very much like football.

"It's very carefully planned out. It's actually very much like football, you know. There are plays. You just got to look for holes in her defensive end," explained Jake, before he realized the gaffe and rectified it with "I'm sorry! I didn't mean it like that!"

Watch Jake Gyllenhaal's interview in The David Letterman Show below:


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