Eli Manning's big game propelled the New York Giants to a convincing 45-14 road victory over the listless Washington Redskins on NFL Thursday Night Football.

The N.Y. quarterback fired four touchdowns passing for 300 yards on an efficient 29-of-38 completions. Wide receiver Larry Donnel caught three of those 3 TD passes finishing with 54 yards for the night while Victor Cruz ended up with 108 yards on 6 receptions.

The Redskins, still playing without star QB Robert Griffin III, had a total of six turnovers. Four came from starting QB Kirk Cousins who was intercepted four times. Cousins finished with 257 passing yards on 19-of-33 completions.

The ground game opened up the field for Manning and the Giants, which had 154 rushing yards to Washington's 86. Running backs Rashad Jennings and Andre Williams rushed for a combined for 121 yards on 28 carries.

The Giants built a 24-7 lead at the halftime break and never looked back. New York improved to a 2-2 record for the season and bounced back with back-to-back wins after a 0-2 start this season. Washington is going into the opposite direction dropping to a 1-3 win-loss record with back-to-back losses after splitting their first two games.

View the slideshow for more images from the Giants vs. Redskins match-up in the NFL.

New York Giants quarterback Eli Manning
New York Giants quarterback Eli Manning (10) throws the ball against the Washington Redskins in the first quarter at FedEx Field. Reuters
New York Giants defensive tackle Cullen Jenkins
New York Giants defensive tackle Cullen Jenkins (99) recovers a fumble against the Washington Redskins in the first quarter at FedEx Field. Reuters
New York Giants wide receiver Rueben Randle
New York Giants wide receiver Rueben Randle (82) carries the ball as Washington Redskins strong safety Bashaud Breeland (26) chases in the first quarter at FedEx Field. Reuters
New York Giants tight end Larry Donnell
New York Giants tight end Larry Donnell (84) is tackled by Washington Redskins inside linebacker Perry Riley (56) during the first half at FedEx Field. Reuters
New York Giants tight end Larry Donnell
New York Giants tight end Larry Donnell (84) catches the ball to score a touchdown as Washington Redskins strong safety Bashaud Breeland (26) defends in the second quarter at FedEx Field. Reuters
New York Giants cornerback Trumaine McBride
New York Giants cornerback Trumaine McBride (38) recovers a fumble by Washington Redskins tight end Logan Paulsen (82) in the second quarter at FedEx Field. Reuters
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