Hollywood top talk show host Oprah Winfrey denied once again that she is a lesbian. Winfrey said that rumors of her alleged lesbianism irritates her because that means some people would think she is lying.

"I'm not even kind of a lesbian," Oprah tells Barbara Walters in an interview on ABC.

"And the reason why... irritates me is because it means that somebody must think I'm lying. That's number one. Number two why would you want to hide it? That is not the way I run my life."

Rumors of Oprah's lesbianism largely focused on her friend Gayle King, who is the editor-at-large of O, The Oprah Magazine. She is Oprah's bestfriend, and she herself has previously worked as a television news anchor and talk show host. Winfrey says that she and Gayle has a close relationship, but in a very different way.

"She is the mother I never had. She is the sister everybody would want. She is the friend that everybody deserves. I don't know a better person. I don't know a better person," Winfrey said of Gayle King.

"It's making me cry because I'm thinking about how much I probably have never told her that. Tissue, please. I now need tissue. I've never told her that."

Oprah Winfrey's interview will Barbara Walter will air on Thursday at 9 p.m. ET on ABC. The occasion for the interview is the end of The Oprah Winfrey Show next May and the launch of her new cable network, OWN, The Oprah Winfrey Network.