Planning Minister John Day has announced that the State Government is calling for expressions of interest in purchasing land in the Perth City Link located in Western Australia, touted as the most significant inner-city development opportunity in more than a century.

Day said in a statement posted on his website that more than five hectares of prime land was available for development to deliver a range of residential, commercial, retail and tourism facilities.

"To meet the challenges of the fastest population growth in the nation, Perth must continue to provide new opportunities for people to live and work in the city," he said.

According to Day, the Perth City Link project will transform the heart of Perth by changing the orientation of the city to connect the CBD with the entertainment precinct of Northbridge.

He said the Link project will remove a 100-year old barrier in the city and "deliver significant benefits including improved public safety, access and connectivity - all funding and statutory approvals for this project are in place and works are well under way on site."

The Perth City Link is envisioned to become the main driver of CBD accommodation beyond 2015 by providing more than 250,000 square meter of new retail and commercial space and 1,650 new dwellings.

The 5.2 hectares available for development has the potential to deliver more than 250,000 sqm in gross floor area.

"The State Government is looking for developers with the appropriate experience and capacity to deliver high quality, environmentally sustainable designs and an active precinct for all West Australians to enjoy," the Minister said.

He said the investment by the State Government in the project is encompasses the rail line, develop an underground bus station, complete the new 15,500 seat Perth Arena, and deliver high quality public spaces such as City Square.

"In addition, a key outcome of the project is the delivery of much-needed hotel accommodation to meet the growing demands of the WA tourism and business markets. Perth City Link is one of a number of major redevelopment projects, including Perth Waterfront; Perth Cultural Centre; and Riverside, which are currently planned or under way across our city," Day said.

The Link project is a collaboration of three levels of government: the Federal Government; the State Government led by agencies EPRA (East Perth Redevelopment Authority) and the Public Transport Authority and the City of Perth.

"Perth City Link has moved well into delivery phase of the project with demolition of the Perth Entertainment Centre and the commencement of works to sink a section of the Fremantle rail line. At the western end of the project, works are also being undertaken to create two development sites, upgrade critical services infrastructure and create a new public space," he said.

Expressions of Interest are open until November 10. The shortlisted proponents will be invited to submit detailed proposals early next year.