Sandra Oh is the first among the six remaining original cast of Grey's Anatomy to officially announce she is quitting the series after Season 10. Series creator Shonda Rhimes has expressed her thoughts on the news.

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Sandra Oh is the first among the six remaining original cast of Grey’s Anatomy to officially announce she is quitting the series after Season 10. Series creator Shonda Rhimes has expressed her thoughts on the news. (Collage: Tumblr user @itscharlotteking)

"I love spending time with Sandra, and as a writer, writing for Sandra is one of the best things that's ever happened to me. I would hope that it wouldn't be happening -- but I also know Sandra, and I know that it's time for her to have new challenges," Shonda Rhimes told The Hollywood Reporter.

Cristina Yang is one of the most beloved characters in Grey's Anatomy. As Meredith Grey's best friend, Sandra Oh has always been brilliant in playing such a fiery character. But the time has come for Cristina to be let go, Oh said.

First thing I'm gonna do when I'll be home is that I'm gonna write Sandra Oh a letter to tell her how great she is. She's so amazing.

— Grey's Anatomy (@GreysCrew) August 14, 2013

Sandra Oh went trending on Twitter soon after The Hollywood Reporter broke the news that Cristina Yang will exit the series after Grey's Anatomy Season 10.

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There is no word yet whether Cristina Yang will die like Mark Sloan (Eric Dane), Lexie Grey (Chyler Leigh) and George O'Malley (T.R. Knight). But avid Yang and Crowen fans are already inconsolable. A lot of Crowen followers were still hopeful that Cristina and Owen Hunt will find a way to still be together. Until reports of Yang's imminent exit came out.

"Sandra Oh will no longer be on the show" me: pic.twitter.com/wa1vDM3Rcu — alex vause♡ (@Lovewilllast_) August 13, 2013

Here are the Top 3 Ways Cristina Yang could exit the show without dying. Grey's Anatomy creator Shonda Rhimes has earned a reputation for killing off her characters. But Sandra's fans are hoping for a better exit for her.

3. Job offer. Cristina Yang is a celebrated cardiothoracic surgeon. Hospitals were clamouring to get her attention even before the Boards.

2. Break-up with the Chief. Yang should give Owen Hunt some space to heal. It happens in break-ups. S

1. Fly off to another state with Meredith Grey and Derek Shepherd. There has been no official release yet from Ellen Pompeo and Patrick Dempsey. But these two might also exit the show after their contracts expire at the end of Grey's Anatomy Season 10. Meredith and Cristina being inseparable, the latter could fly to another state with MerDer for a new chapter in their lives.

Scroll down to watch some of the best Cristina Yang compilation videos on YouTube.

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VIDEO: Cristina Yang's Best Moments