Novak Djokovic dominated Spaniard Marcell Granollers in straight sets, 6-3, 6-0, 6-2 in the fourth round of the 2013 U.S. Open. The Serbian has yet to lose a set in this tournament and will meet Mikhail Youzhny in the quarterfinals.

Who has the best chance to beat the 6-time Grand Slam title winner?

READ ALSO: U.S. Open: Who Can Beat Novak in New York? (Part 1)

David Ferrer (Spain) vs. Djokovic
Head-to-head: 5 wins vs. 10 losses
Last match: 2013 Loss – Australian Open (Australia) Semifinals, 2-6, 2-6, 1-6
Last win: 2007 – ATP World Tour Finals (Great Britain) Round-robin, 6-3, 6-1

Since 2012, Ferrer has made at least the quarterfinals of all seven Grand Slam tournaments he joined in this stretch. The Spaniard has 20 career Singles titles but has never won a Grand Slam. Can he finally break the streak this year? Or will Djokovic stop him again?

Tommy Robredo (Spain) vs. Djokovic
Head-to-head: 1 win vs. 5 losses
Last win: 2005 - ATP Masters Series (France), Round of 64, 6-4, 6-3
Last match: 2009 Loss - ATP World Masters (Italy) Round of 16, 6-1, 6-1

Robredo has so far fried the biggest fish in this tournament with his straight sets upset win over Roger Federer. The Spaniard beat the Swiss, 7-6(3), 6-3, 6-4 in the previous round and will face compatriot Rafael Nadal in the quarterfinals.

Stanislas Wawrinka (Switzerland) vs. Djokovic
Head-to-head: 2 wins vs. 12 losses
Last win: 2006 Vienna (Austria) Round of 16, 6-3, 6-3
Last match: 2013 Loss - Australian Open (Australia) Round of 16, 6-1, 5-7, 4-6, 7-6(5), 10-12

Wawrinka took care of business against Tomas Berdych in four sets, 3-6, 6-1, 7-6 (8), 6-2 to set up a quarters date with Andy Murray. One of the most memorable games in his career so far happened at the 2013 Australian Open when he took Djokovic to a classic 5th set where he lost the match via a tie-breaker.

Andy Murray (Great Britain) vs. Djokovic
Head-to-head: 8 wins vs. 11 losses
Last win: 2013 Wimbledon (Great Britain) Final, 6-4, 7-5, 6-4
Last match: 2013 Win - Wimbledon (Great Britain) Final, 6-4, 7-5, 6-4

While Murray has losing record (8-11) against Djokovic, his last three wins against the Serbian went down in the big tournaments-- at the final of the 2012 US Open, the championship at the London Olympics also in 2012 and last year’s convincing straight sets win in the Wimbledon Final in 2013. Murray takes on Stanislas Wawrinka in the quarterfinals and will meet Djokovic in the semifinal if both top seeds win their respective matches.

U.S. Open – Men’s Singles Quarterfinals Pairing:
Mikhail Youzhny vs. Novak Djokovic
Andy Murray vs. Stanislas Wawrinka
Richard Gasquet vs. David Ferrer
Tommy Robredo vs. Rafael Nadal