The end to eight division boxing title holder Manny Pacquiao's 18-year boxing career appears to be in sight. Freddie Roach, the coach of the Filipino champ, said on Wednesday that the champ would retire from professional boxing if he loses his bout with American boxer Brandon Rios on Nov 24 in Macau, China.

It will be held at the Venetian Macao and is a non-title welterweight bout, which could cap his 54-5-2 record.

Roach said he and Manny have agreed that the deciding factor in plotting the future of Pacquiao in boxing depends on the result of his match with Rios, who has a 31-1-1 record. His sole loss was in the hands of American boxer Mike Alvarado held in Las Vegas on March 30, 2013. Here are the highlights of that bout.

"It's over, 100 per cent [if Pacquiao is knocked out by Rios]," Roach said, adding, "We have a deal. When I tell him it's over, he'll say it's over and that's it. He's pretty loyal with his words and if that happens, it will be the end," GMA News Online quoted the American coach.

Pacquiao lost his last two fights to Mexican boxer Juan Manuel Marquez in December 2012 and American pugilist Timothy Bradley in June 2012.

Since his last heartbreaking losses, there have been speculations that Manny will soon hang up his boxing gloves even as his mother, Dionesia, urged him to retire from the gory and violent sport that has brought financial relief and wealth to Pacquiao family in what is one of the most dramatic rags-to-riches stories in the Philippines.

American boxer Floyd Mayweather Jr, who has a match with undefeated Mexican boxer Saul Alvarez in Las Vegas on Sept 14, has written Pacquiao off in a future fight. Even Roach has admitted that Manny, now a congressman, has yet to begin training for his bout with Rio which is only four months away.

However, Roach refuses to see Pacquiao's defeat in the hands of Rios. "The thing is, people look at the losses and they think the reason is that he's getting old. That's not the case, not from what I see," he insisted.